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Whole-Brain Ultrastructural Mapping

Mammalian whole-brain ultrastructural mapping is fast approaching reality, with the mouse brain being the first target. These types of maps will provide complete wiring diagrams of the whole brain, allowing for the first time an understanding of how the most complicated thing in the known universe is put together.

Rapid progress is being made. Stay tuned.



The Road to the Whole Brain

The path to mapping the complete circuit of the whole mouse brain is shown below.




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Staining the Whole Mouse Brain for Electron Microscopy

Our new article has appeared in Nature Methods over staining the whole mouse brain and evaluating axon traceability. Read more about it at the Nature website and in a Max Planck Institute press release .




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Whole-Brain Ultrastructural Mapping in the Mouse




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Brain Preservation Contest

We have entered the Brain Preservation Contest, whose first goal is optimal whole-brain ultrastructural preservation in the mouse.




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Join Us at SFN 2011

Sun, Nov 13, 2:00 - 3:00 PM, 304.14/XX66 - Whole-brain ultrastructural staining in the mouse




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    Copyright 2012-2013, Ultrastructural Brain Mapping Consortium
    All rights reserved.
For the supreme cunning of the structure of the gray matter is so intricate that it defies and will continue to defy for many centuries the obstinate curiosity of investigators.

- Santiago
Ramón y Cajal


Ultrastructural Data

Scanning Electron Microscopy
(80 nm pixel size)



Light Microscopy Data

Nissl (from BrainMaps.org)

Myelin (from BrainMaps.org)

Allen Brain Atlas
(from Brain-Map.org)